CancerDAP

CancerDAP is a database molecularly characterizing subpathways involved in cellular response to 191 anticancer drugs. Pharmacological and genomic data sets were collected from CellMiner database. These close connected subpathways capture the comprehensive effects of multiple genetic and epigenetic (gene expression, copy number variation and DNA methylation) alterations and gene-gene interactions in biological pathways on drug sensitivity in virtue of simulated annealing. CancerDAP currently covers 2751 subpathways associated with 191 anticancer drugs identified in 141 KEGG pathways. Here, the entry for each subpathway in the database provides comprehensive information such as its size, function, structure, significance, three omics features and its member genes correlation with corresponding anticancer drug across NCI-60 cell lines.

Currently, user can

1. Prospect the detailed information of each subpathway related to corresponding anticancer drug; 2. Explore the precise correlations between anticancer drug response and member genes within subpathways at three molecular levels; 3. Inspect the subpathway structure covering important genes, interaction partners and regulation patterns at global views in KEGG pathway.