Human proteins interact with viral proteins
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Understanding the mechanisms of viral infectious diseases remains great challenge. Protein-protein interactions (PPIs) provide the interface between a virus and host cells. HVPPI (Human-Virus Protein-Protein Interactions) provide a comprehensively annotated human-virus protein interactions as well as online tools for functional analysis of PPIs. Currently, HVPPI included 27293 experimentally validated human-virus PPIs, covering 8 virus families, 140 virus proteins and 6059 human proteins. Furthermore, numbers of tools were provided to visualized the PPIs or function predictions.
| Data summary | Number |
|---|---|
| Virus type | 13 |
| Virus type classification | Zika virus (ZIKA), Dengue virus (DENV), SARS-CoV-1, SARS-CoV-2, MERS-CoV, human immunodeficiency virus (HIV), Hepatitis C virus (HCV), Ebola virus (EBOV), Influenza A virus (H1N1), human papilloma virus (HPV), influenza A/B/C virus (InfluV), La Crosse virus (LACV), adeno-associated virus type 2 (AAV-2) |
| Virus family | 8 |
| Virus family classification | Bunyaviridae(LACV); Picornaviridae(AAV-2); Coronaviridae(SARS-CoV-1, SARS-CoV-2, MERS-CoV); Filoviridae(EBOV); Papillomaviridae(HPV); Flaviviridae(ZIKA, DENV, HCV); Orthomyxoviridae(H1N1, InfluV); Retroviridae(HIV) |
| Human-virus PPIs | 27293 |
| Virus proteins | 140 |
| Human proteins | 6059 |
Contact Us:
If you have any questions or suggestions, please do not hesitate to contact Yongsheng Li(professor).
- Key Laboratory of Tropical Translational Medicine of Ministry of Education, College of Biomedical Information and Engineering
- Hainan Medical University
- Haikou 571199, China
- Please email:liyongsheng@hainmc.edu.cn