The mutual interactions between the nervous system and cancer have become increasingly evident. Diverse neural pathways contribute to the pathogenesis of malignancies and have been emerged as an important component of the tumor microenvironment. Neuro_Cancer was constructed for comprehensive evaluating the neural signal across cancer types. In total, Neural_Cancer evaluated 11 neural signal pathway activities across 9229 samples from 27 cancer types. Interactions among 251 immunology signatures from three immune features and neural signal pathway were investigated. In addition, the spatial patterns of neural signal pathways were explored in 630,158 spots of 239 slices from 22 cancer types. Correlation between the neural signal pathway activities and 198 drugs were also included in Neural_Cancer. Neuro_Cancer enable interactively data exploration of neural signal activity in various cancers, neural-immune interaction patterns, spatial characteristics of neural signals in cancer, and the association between neural signals and drug sensitivity. Neural_Cancer serves as a comprehensive data resource for investigating the interactions between neural signals and cancer.