Welcome to PRES!
PRES decode the functional perturbations of RNA Editing Sites based on Editome profiling.
After users uploading an editome profile in samples of different groups, PRES will
finish annotation of various genomic elements and detect differential-editing sites under the user-selected
method and threshold.
interpret the downstream functional perturbations of differential-editing sites from four different levels:
i) gain or loss regulations of miRNAs or RNA-binding proteins;
ii) RNA secondary structure changes or locating at the protein structural region;
iii) changes of amino acid composition by non-synonymous editing sites;
iv) the significantly enriched biological functions or pathways.
genes with the top-scoring of functional perturbation degree will be listed to assist the user for further investigation.