Highlights

RBPreg is a computational method to identify the RBP regulators by integration of single cell RNA-seq and RBP binding data. We first de novo scanned the gene and identified the RBP motifs in gene sequences. All protein genes were ranked based on the significance levels. Next, the RBP-gene regulatory correlations were evaluated based on the expression correlation between RBP and gene. Finally, the activities of RBPs in specific cell types were evaluated by AUCell.