Introdution

The initiation and progression of disease is relevant with the aberrant expression of both protein coding and non-coding genes. Increasing evidences demonstrated that the long non-coding RNAs (lncRNAs) play important roles in various biological processes and development of diseases through mediating their specific biological pathways. LncSubpathway system provides a flexible platform to explore the functional roles of lncRNAs by integrating matched lncRNA-mRNA expression profiles and pathway topologies. LncSubpathway identifies the most relevance pathway regions that related with risk lncRNAs and implicated with study conditions through simultaneously considering dysregulation of lncRNAs and PCGs and correlation changes of interactions.

LncSubpathway provides an analysis platform for identifying transcriptional dysregulation of subpathway regions that associated with risk lncRNAs. Furthermore, the LncSubpathway system provides two flexible ways to visualize subpathways. Please select "Help" for more details on LncSubpathway.

Citing LncSubpathway
To cite your use of the LncSubpathway, please reference: LncSubpathway: a novel approach for identifying dysfunctional subpathways associated with risk lncRNAs by integrating lncRNA and mRNA expression profiles and pathway topologies. (PMID:28152521)