Details
Disease Name Parkinson Disease
Nocoding RNA Name hsa-miR-4519
Expression Pattern mutated
Species Homo sapiens
Detection Methods Quantitative-PCR,Luciferase Reporter Assay etc.
Target NSF
Tissue brain
Treatment N/A
PubMed ID 26670097
Year 2015
Detail Description we identified rs897984:T>C in miR-4519 (p-value = 1.3×10-5 and OR = 0.93) and rs11651671:A>G in miR-548at-5p (p-value = 1.1×10-6 and OR = 1.09) to be associated with PD. We showed that the variant's mutant alleles change the secondary structure and decrease expression level of their related miRNAs.Among them, we experimentally showed that NSF is a direct target of miR-4519.

 

NSDNA: The Nervous System Disease NcRNAome Atlas

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