Disease Name |
Alzheimer Disease |
Nocoding RNA Name |
mmu-miR-294 |
Expression Pattern |
down-regulated |
Species |
Mus musculus |
Detection Methods |
qRT-PCR,Luciferase Reporter Assay etc. |
Target |
APP |
Tissue |
brain |
Treatment |
N/A
|
PubMed ID |
24022509 |
Year |
2013 |
Detail Description |
We found for the first time miRNAs that were inversely regulated in AD and EE, and may affect synaptic proteins and modulators, molecular factors associated with AD pathology, and survival and neuroprotective factors. MiRNAs that were upregulated only in 3xTgAD mice model of AD compared with their control mice were localized to synapses, predicted to downregulate essential synaptic proteins and are highly associated with regulating apoptosis, AD-associated processes and axon guidance. |
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