Disease Name |
Alzheimer Disease |
Nocoding RNA Name |
hsa-miR-146a |
Expression Pattern |
up-regulated |
Species |
Homo sapiens |
Detection Methods |
miRNA array,Western Blot,Luciferase Reporter Assay etc. |
Target |
CFH |
Tissue |
brain(Human neural cells) |
Treatment |
N/A
|
PubMed ID |
19540598 |
Year |
2009 |
Detail Description |
These data suggest that (1) as in AD brain,NF-jB-sensitive,miRNA-146a mediated,modulation of CFH gene expression may contribute to inflammatory responses in aluminum-stressed HN cells,and (2) underscores the potential of nanomolar aluminum to drive genotoxic mechanisms characteristic of neurodegenerative disease processes. |
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