Disease Name |
Alzheimer Disease |
Nocoding RNA Name |
hsa-miR-181c |
Expression Pattern |
down-regulated |
Species |
Homo sapiens |
Detection Methods |
qRT-PCR,Western Blot,Luciferase Reporter Assay etc. |
Target |
SPTLC1 |
Tissue |
brain |
Treatment |
N/A
|
PubMed ID |
21994399 |
Year |
2011 |
Detail Description |
We identified that the loss of miR-137,-181c,-9,and 29a/b-1 increases SPT and in turn Aβlevels,and provides a mechanism for the elevated risk of AD associated with age,high-saturated-fat diet,and gender.Finally,these results suggest SPT and the respective miRNAs may be potential therapeutic targets for sporadic AD. |
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