Disease Name |
Alzheimer Disease |
Nocoding RNA Name |
mmu-miR-16 |
Expression Pattern |
up-regulated |
Species |
Mus musculus |
Detection Methods |
SemiQuantitative RT-PCR,Real-time RT-PCR,Western Blot,Luciferase Reporter Assay etc. |
Target |
APP |
Tissue |
brain |
Treatment |
N/A
|
PubMed ID |
20619502 |
Year |
2012 |
Detail Description |
Overexpression of miR-16,both in vitro and in vivo,led to reduced APP protein expression.Taken together,these findings demonstrate that APP is a target of miR-16 and the abnormally low expression of miR-16 could potentially lead to APP protein accumulation in AD mice. |
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