NSDNA: The Nervous System Disease NcRNAome Atlas

Details

Disease Name	Peripheral Nerve Injuries
Nocoding RNA Name	mmu-miR-383
Expression Pattern	down-regulated
Species	Mus musculus
Detection Methods	miRNA array, Quantitative Real-time PCR etc.
Target	N/A
Tissue	nerve(dorsal root ganglion)
Treatment	N/A
PubMed ID	21853131
Year	2011
Detail Description	Results showed that 20 miRNA transcripts displayed a significant change in expression levels, with 8 miRNAs transcripts being altered by more than 1.5-fold. Using quantitative reverse transcription PCR, we demonstrated that one of these miRNAs, miR-21, was upregulated by 7-fold in the DRG at 7 days post-axotomy. In dissociated adult rat DRG neurons lentiviral vector mediated overexpression of miR-21 promoted neurite outgrowth on a reduced laminin substrate. miR-21 directly downregulated expression of Sprouty2 protein, as confirmed by Western blot analysis and 39 untranslated region (UTR) luciferase assays.

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