Details
Disease Name Peripheral Nerve Injuries
Nocoding RNA Name rno-miR-203
Expression Pattern down-regulated
Species Rattus norvegicus
Detection Methods microarray, qRT-PCR, Luciferase Reporter Assay, Western Blot etc.
Target Rap1a
Tissue spinal cord(spinal dorsal horn)
Treatment N/A
PubMed ID 24451631
Year 2015
Detail Description This study revealed substantially (~ 10-fold) decreased miR-203 expression in the spinal dorsal horns, but not the dorsal root ganglions, hippocampus, or anterior cingulate cortexes of bCCI rats. Rap1a protein expression was up-regulated in bCCI rat spinal dorsal horns. We further verified that miR-203 directly targeted the 3’-untranslated region of the rap1a gene thereby decreasing rap1a protein expression in neuron-like cells.

 

NSDNA: The Nervous System Disease NcRNAome Atlas

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