| Disease Name |
Peripheral Nerve Injuries |
| Nocoding RNA Name |
rno-miR-203 |
| Expression Pattern |
down-regulated |
| Species |
Rattus norvegicus |
| Detection Methods |
microarray, qRT-PCR, Luciferase Reporter Assay, Western Blot etc. |
| Target |
Rap1a |
| Tissue |
spinal cord(spinal dorsal horn) |
| Treatment |
N/A
|
| PubMed ID |
24451631 |
| Year |
2015 |
| Detail Description |
This study revealed substantially (~ 10-fold) decreased miR-203 expression in the spinal dorsal horns, but not the dorsal root ganglions, hippocampus, or anterior cingulate cortexes of bCCI rats. Rap1a protein expression was up-regulated in bCCI rat spinal dorsal horns. We further verified that miR-203 directly targeted the 3’-untranslated region of the rap1a gene thereby decreasing rap1a protein expression in neuron-like cells. |
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