NSDNA: The Nervous System Disease NcRNAome Atlas

Details

Disease Name	Alzheimer Disease
Nocoding RNA Name	hsa-miR-15b-3p
Expression Pattern	down-regulated
Species	Homo sapiens
Detection Methods	Next-generation Deep sequencing,qRT-PCR etc.
Target	N/A
Tissue	serum
Treatment	N/A
PubMed ID	25349172
Year	2015
Detail Description	14 miRNA were found to be upregulated (hsa-miR-361-5p, hsa-miR-30e-5p, hsa-miR-93-5p, hsa-miR-15a-5p, hsa-miR-143-3p, hsa-miR-335-5p, hsa-miR-106b-5p, hsa-miR-101-3p,hsa-miR-424-5p, hsa-miR-106a-5p, hsa-miR-18b-5p, hsa-miR-3065-5p, hsa-miR-20a-5p and hsa-miR-582-5p) and three miRNA were found to be downregulated (hsa-miR-1306-5p, hsa-miR-342-3p and 15b-3p). As qRT-PCR could not detect hsa-miR-3065-5p in all samples by qRT-PCR, this miRNA was removed from the list of biomarker candidates.Upon validation by qRT-PCR, 16-miRNA were successfully detected and displayed consistent miRNA expression changes within AD participants when compared with expression changes detected by NGS.hsa-miR-1306-5p contributes more towards clinical classification than age, indicating this miRNA as vitally important in class separation.

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