Disease Name |
Alzheimer Disease |
Nocoding RNA Name |
mmu-miR-29c |
Expression Pattern |
down-regulated |
Species |
Mus musculus |
Detection Methods |
RT-PCR,transfection,Western Blot,Luciferase Reporter Assay,Immunohistochemistry etc. |
Target |
NAV3 |
Tissue |
hippocampus and the frontal cortex |
Treatment |
N/A
|
PubMed ID |
26212654 |
Year |
2015 |
Detail Description |
We observed that miR-29c directly mediated downregulation of NAV3 protein expression in vitro.Our results showed that miR-29c was one of the multiple miRNAs that regulate expression of NAV3 and suggested that miR-29c may play a vital role in AD neurodegenerative processes by regulating NAV3 expression,as well as other miR-29c targets such as BACE1,at least in the young AD mouse. |
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