| Details |
| Disease Name | Alzheimer Disease |
| Nocoding RNA Name | hsa-miR-154 |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | Isolation of BDMs,Flow Cytometry,Chemotaxis Assay,Phagocytosis Assay,qRT-PCR,ELISA etc. |
| Target | CCR2 |
| Tissue | Peripheral blood mononuclear cells (PBMCs) |
| Treatment | N/A |
| PubMed ID | 27239545 |
| Year | 2016 |
| Detail Description | The chemokine/chemokine receptor CCL2/CCR2 axis was impaired in BDMs from AD and MCI patients, causing a deficit in cell migration.Immune-related microRNAs (miRNAs),including miR-155, -154, -200b, -27b,and -128, were found to be differentially expressed in AD and MCI patients.All five miRNAs were overexpressed in BDMs from AD patients.MiR-154 and miR-23a share CCR2 as a predictive target,whereas miR-27b has been shown to regulate the CXCL12/CXCR4 axis, the observed increase in these miRNAs may contribute to the impairments observed in cell migration.TREM2 expression is increased in MCI patients. |
NSDNA: The Nervous System Disease NcRNAome Atlas
Contact wanglh211@163.com for inquiries and feedback
© All right reserved 2016