| Details |
| Disease Name | Alzheimer Disease |
| Nocoding RNA Name | hsa-miR-34a |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | qRT-PCR,Western Blot etc. |
| Target | TLX2 |
| Tissue | temporal cortex (TC), frontal cortex (FC), and cerebellum (CB) |
| Treatment | N/A |
| PubMed ID | 27235866 |
| Year | 2016 |
| Detail Description | MiR-34a that is over expressed in specific brain regions of AD patients as well as in the 3xTg-AD mouse model.MiR-34a overexpressed neurons secrete miR-34a containing exosomes that are taken up by neighboring neurons.MiR-34a targets dozens of genes whose expressions are known to be correlated with synchronous activity in resting state functional.Our analysis of human genomic sequences from the tentative promoter of miR-34a gene shows the presence of NFkB, STAT1, c-Fos, CREB and p53 response elements. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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