| Details |
| Disease Name | Myasthenia Gravis, Autoimmune, Experimental |
| Nocoding RNA Name | hsa-miR-181c |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | Real-time Quantitative RT-PCR,Luciferase Reporter Assay etc. |
| Target | IL-7 |
| Tissue | blood(Peripheral blood mononuclear cells) |
| Treatment | N/A |
| PubMed ID | 25962782 |
| Year | 2015 |
| Detail Description | To explore the role of miR-181c in the pathogenesis of MG, we separated the PBMCs from the patients and healthy controls, and real-time quantitative RT-PCR was used to detect the expression of miR-181c. expression of miR-181c in generalized MG or ocular MG patients was significantly lower than in healthy controls.Using a luciferase reporter assay, we found that wildtype IL-7 3-UTR luciferase activity was significantly suppressed by cotransfected miR-181c mimics in comparison with nontargeting miRNA. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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