| Details |
| Disease Name | Alzheimer Disease |
| Nocoding RNA Name | BACE1AS |
| Expression Pattern | up-regulated |
| Species | Homo sapiens |
| Detection Methods | siRNA,RT-qPCR etc. |
| Target | N/A |
| Tissue | brain(cortex) |
| Treatment | N/A |
| PubMed ID | 24857657 |
| Year | 2014 |
| Detail Description | HuD also associated with and stabilized the long noncoding (lnc)RNA BACE1AS, which partly complements BACE1 mRNA and enhances BACE1 expression. Consistent with HuD promoting production of APP and APP-cleaving enzyme, the levels of APP, BACE1, BACE1AS, and Abeta were higher in the brain of HuD-overexpressing mice. Importantly, cortex (superior temporal gyrus) from patients with AD displayed significantly higher levels of HuD and, accordingly, elevated APP, BACE1, BACE1AS, and Abeta than did cortical tissue from healthy age-matched individuals. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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