| Details |
| Disease Name | Parkinson Disease |
| Nocoding RNA Name | hsa-miR-34b |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | Quantitative Real-time PCR,Reporter gene assay etc. |
| Target | a-syn |
| Tissue | SH-SY5Y cell line |
| Treatment | N/A |
| PubMed ID | 25541488 |
| Year | 2015 |
| Detail Description | To verify whether miR-34b and miR-34c directly target the 3-UTR of a-syn mRNA, we utilized a plasmid construct expressing full-length a-syn 3-UTR downstream of the firefly luciferase reporter gene. Co-transfection of miR-34b or miR-34c along with this reporter construct significantly decreased luciferase activity, but did not affect the control vector pGL3 devoid of thea-syn 3-UTR, indicating that miR-34b and miR-34c work through the 3-UTR of a-syn. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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