A Web Server to Investigate the Effect of DNA Methylation-related Functional Elements on Prognosis.

The functional elements associated with DNA methylation, for example enhancer region, CpG island, shore, shelf, promoter, gene body, etc., are discovered to be underlying prognostic markers for patients' survival.Here, we built a web server SurvivalMeth (freely available via a user friendly web-server at http://bio-bigdata.hrbmu.edu.cn/survivalmeth/) to investigate the effect of DNA methylation-related functional elements on prognosis, and multiple kinds of commonly used functional elements associated with DNA methylation are considered.

The prognostic analysis of functional elements was mainly performed based on three ways: genes, the combination of multiple genes or functional elements, and enhancer region, and the prognostic analysis was accomplished through two steps: proportional hazards regression model and survival analysis. The corresponding detailed statistic results of prognostic analysis will be shown at the tables and pictures. Furthermore, the frequently used data from TCGA, CCLE and GEO was prestored into SurvivalMeth, including 81 DNA methylation profiles in 13371 samples across 36 cancers, covering more than 480000 DNA methylation sites locating in 19000 coding genes, 1689653 super enhancers, 1304902 CTCF binding regions, 77634 repeat elements and multiple functional elements such as CpG island, shore, shelf, promoter, gene body, exon, etc. In order to satisfy the more customized prognostic analysis of DNA methylation-related functional elements, SurvivalMeth supports the uploading of user-provided data of DNA methylation and functional elements. In summary, SurvivalMeth could customize the analysis between DNA methylation-related functional elements and prognosis comprehensively and easily.


The Distribution of Samples in Different Cancers and Platforms
The Distribution of Elements in Different Cancers and Platforms



Please send a email to lixia@hrbmu.edu.cn, xujuanbiocc@ems.hrbmu.edu.cn.
when you have any question or problem about using SurvivalMeth.
Please cite: SurvivalMeth: A Web Server to Investigate the Effect of DNA Methylation-related Functional Elements on Prognosis.