Details
| Name | TP53 |
| Type | gene |
| Species | Rat Rattus |
| Tissue | cortical primary neurons |
| Experiment Method | Knockdown,other |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | We first tested whether p53 contributes to p25-induced cell death by cotransfecting cortical neurons with p25-GFP, together with either a control siRNA vector or p53 siRNA vector. Knockdown of p53 provided a 25% increase in cell survival. |
| Regulation Gene | NA |
| Year | 2007 |
| Pubmed ID | 17581637 |
| Title | SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. |
| Drug | NA |
| Disease | AD,ALS |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |