A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name TP53
Type gene
Species Mus musculus
Tissue MEFs
Experiment Method Western,other
Up/Down NA
Pro/Anti Pro
Funtion Description p53(S18A) animals exhibited several aging-associated phenotypes early, and murine embryonic fibroblasts from these animals underwent early senescence in culture. Together, these data indicate that the ATM/ATR phosphorylation site Ser(18) on p53 contribute
Regulation Gene NA
Year 2007
Pubmed ID 18089799
Title The ataxia telangiectasia-mutated target site Ser18 is required for p53-mediated tumor suppression.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA