Details
| Name | APOE |
| Type | gene |
| Species | Mus musculus |
| Tissue | brain tissues |
| Experiment Method | ;Western Blotting and Co-immunoprecipitation |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | In aging brains, the increased apoE4 aggregation and compromised endosomal function further exacerbate the inhibitory effects of apoE4 on insulin signaling and related functions. Together, our study provides novel mechanistic insights into the pathogenic |
| Regulation Gene | NA |
| Year | 2017 |
| Pubmed ID | 28957663 |
| Title | Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes. |
| Drug | NA |
| Disease | Alzheimer's disease |
| Environment Factors | high-fat diet |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |