A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name TP53
Type gene
Species Mus musculus
Tissue NA
Experiment Method other
Up/Down NA
Pro/Anti Pro
Funtion Description Loss of function mutations in the p53 tumor suppressor gene predispose mice and humans to cancer, resulting in abbreviated life spans. A dominant mutation in the murine HD gene, similar to mutations that cause Huntington's disease in humans, reverses some
Regulation Gene NA
Year 2008
Pubmed ID 18242663
Title Mutant alleles of HD improve the life span of p53(-/-) mice.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant 1
High-throughput NA