A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name TP53
Type gene
Species Mus musculus
Tissue Fibroblast lines
Experiment Method Western Blot,other
Up/Down NA
Pro/Anti Pro
Funtion Description TPPII deficiency activates cell type-specific death programs, including proliferative apoptosis in several T lineage subsets and premature cellular senescence in fibroblasts and CD8(+) T cells. This coincides with up-regulation of p53 and dysregulation of
Regulation Gene NA
Year 2008
Pubmed ID 18362329
Title Activation of cellular death programs associated with immunosenescence-like phenotype in TPPII knockout mice.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA