A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name TP53
Type gene
Species Mus musculus
Tissue NA
Experiment Method qPCR,other
Up/Down Down
Pro/Anti NA
Funtion Description P53 deficiency severely exacerbates tissue degeneration caused by mosaic deletion of the essential genome maintenance regulator Atr. Combined loss of Atr and p53 (Trp53(-/-)Atr(mKO)) led to severe defects in hair follicle regeneration, localized inflammat
Regulation Gene NA
Year 2009
Pubmed ID 19718024
Title Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA