| Name |
TP53
|
| Type |
gene
|
| Species |
Mus musculus
|
| Tissue |
intestinal stem cells
|
| Experiment Method |
PCR,qFISH,Array-CGH,other
|
| Up/Down |
Down
|
| Pro/Anti |
NA
|
| Funtion Description |
Telomere dysfunction limits the proliferative capacity of human cells and induces organismal aging by activation of p53 and p21. Although deletion of p21 elongates the lifespan of telomere-dysfunctional mice. In contrast to p21 deletion, the deletion of p
|
| Regulation Gene |
NA
|
| Year |
2009
|
| Pubmed ID |
19718028
|
| Title |
p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|