| Name |
TP53
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
MSCs
|
| Experiment Method |
RNAi,Immunofluorescence,Western blot
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Activated Wnt/B-catenin signaling can induce MSC aging.The Wnt/B-catenin signaling was a potent activator of reactive oxygen species (ROS) generation in MSCs. After scavenging ROS with N-acetylcysteine, Wnt/B-catenin signaling-induced MSC aging was signif
|
| Regulation Gene |
NA
|
| Year |
2013
|
| Pubmed ID |
23124852
|
| Title |
Wnt/B-catenin signaling induces the aging of mesenchymal stem cells through promoting the ROS production.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|