| Name |
TP53
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
MSC,NPC
|
| Experiment Method |
PCR,Southern Blot,CO-FISH,Western Blot,microarray
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Werner syndrome (WS) patients exhibit premature aging predominantly in mesenchyme-derived tissues, but not in neural lineages, a consequence of telomere dysfunction and accelerated senescence. The cause of this lineage-specific aging remains unknown. Here
|
| Regulation Gene |
NA
|
| Year |
2014
|
| Pubmed ID |
24749076
|
| Title |
Telomerase protects werner syndrome lineage-specific stem cells from premature aging.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|