A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name TRF1
Type gene
Species Mus musculus
Tissue Liver;Heart;Muscle;Brain;Kidney;Bone Marrow;Lung;Intestine
Experiment Method qRT-PCR
Up/Down Down
Pro/Anti Anti
Funtion Description Downregulated genes in the perilesional cortex of the calorie-restricted aged rats, as compared to the perilesional area of ad libitum-fed aged rats, included genes involved in energy homeostasis (Igf1r, Mapk10), apoptosis (Camk2 g), vasculogenesis (Ppp2c
Regulation Gene NA
Year 2017
Pubmed ID 28944611
Title Gene therapy with the TRF1 telomere gene rescues decreased TRF1 levels with aging and prolongs mouse health span
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA