| Name |
TRF2
|
| Type |
gene
|
| Species |
Mus musculus
|
| Tissue |
adult mice (aged 4-5 months)
|
| Experiment Method |
qRT-PCR;ChIP
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Trf2 deletion led to a 320% increase in arterial senescence signaling (P<.05).Trf2 deletion also led to a pro-oxidative arterial phenotype characterized by increased in NADPH oxidase gene expression; a 210% increase in superoxide levels that was partly de
|
| Regulation Gene |
NA
|
| Year |
2019
|
| Pubmed ID |
30502348
|
| Title |
Induced Trf2 deletion leads to aging vascular phenotype in mice associated with arterial telomere uncapping, senescence signaling, and oxidative stress.
|
| Drug |
0
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|