Details
| Name | TRX1 |
| Type | gene |
| Species | Homo sapiens |
| Tissue | skin |
| Experiment Method | Western blot |
| Up/Down | Down |
| Pro/Anti | Pro |
| Funtion Description | Here we find that suppression of TRX1 expression via shRNA rapidly induces premature senescence in young human skin fibroblasts through upregulation of the p53/p21(Cip1/Waf1) and p16(INK4a) tumor suppressor pathways. |
| Regulation Gene | NA |
| Year | 2009 |
| Pubmed ID | 20074557 |
| Title | Suppression of thioredoxin-1 induces premature senescence in normal human fibroblasts. |
| Drug | l-sulforaphane |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |