| Name |
TTP
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
Cervix
|
| Experiment Method |
PCR, Luciferase reporter assay, Western blot, Immunofluorescence
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Here we report on the ability of TTP to act in an anti-proliferative capacity in HPV18-positive HeLa cells by inducing senescence. HeLa cells maintain a dormant p53 pathway and elevated telomerase activity resulting from HPV-mediated transformation, where
|
| Regulation Gene |
NA
|
| Year |
2009
|
| Pubmed ID |
20157568
|
| Title |
The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase
|
| Drug |
NA
|
| Disease |
cervical cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|