| Name |
VentX
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
Human embryonic kidney cell line 293 (HEK293), human cervical cancer cell line HeLa, human osteosarcoma U2OS cell line, and human primary fibroblasts IMR90;Human acute lymphoblastic leukemia cell line Nalm16
|
| Experiment Method |
Western Blotting;Luciferase Reporter Assay;ChIP;RNA Interference;RT-PCR;B-Galactosidase Staining
|
| Up/Down |
Down
|
| Pro/Anti |
Anti
|
| Funtion Description |
Here, we show that VentX is a direct transcriptional activator of p53-p21 and p16ink4a-Rb tumor suppression pathways. Ectopic expression of VentX in cancer cells caused an irreversible cell cycle arrest with a typical senescence-like phenotype. Conversely
|
| Regulation Gene |
NA
|
| Year |
2011
|
| Pubmed ID |
21325273
|
| Title |
VentX trans-activates p53 and p16ink4a to regulate cellular senescence.
|
| Drug |
Doxo and ATRA
|
| Disease |
cervical cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|