| Name |
WIPI1
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
Human myometrium and leiomyoma tissue samples
|
| Experiment Method |
Senescence-associated B-galactosidase (SA-B-gal) staining;SDS-PAGE;Western Blotting;RNA isolation and RT-PCR;Immunohistochemistry (IHC) staining of spheroids
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Overexpression of two selected genes, WIPI1 and SLITKR4, induced cellular senescence in ULM spheroids. Additionally, administration of ABT263 (a BH3 mimetic) effectively reduced the senescent cells induced in ULM spheroids.This study identified novel gene
|
| Regulation Gene |
NA
|
| Year |
2018
|
| Pubmed ID |
30206313
|
| Title |
Application of ex-vivo spheroid model system for the analysis of senescence and senolytic phenotypes in uterine leiomyoma.
|
| Drug |
NA
|
| Disease |
uterine leiomyoma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|