Details
| Name | WRN |
| Type | gene |
| Species | Homo sapiens |
| Tissue | HEK293,U2OS |
| Experiment Method | SIRT1 knock-out,other |
| Up/Down | NA |
| Pro/Anti | Anti |
| Funtion Description | Werner syndrome is an autosomal recessive disorder associated with premature aging and cancer predisposition caused by mutations of the WRN gene. WRN is a member of the RecQ DNA helicase family with functions in maintaining genome stability. |
| Regulation Gene | NA |
| Year | 2008 |
| Pubmed ID | 18203716 |
| Title | Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |