| Name |
YPEL3
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
MCF-7 and ZR-75.1 cells;T-47D cells;SkBr-3 cells
|
| Experiment Method |
Reverse transcription-PCR;Immunoblotting;Senescence-associated B-galactosidase staining
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Here, we identify YPEL3 as a growth suppressive protein downregulated by estrogen in estrogen receptor positive breast cancer cell lines. Estrogen repression of YPEL3 expression was found to be independent of p53 but dependent on estrogen receptor alpha e
|
| Regulation Gene |
NA
|
| Year |
2012
|
| Pubmed ID |
21671470
|
| Title |
Novel senescence associated gene, YPEL3, is repressed by estrogen in ER+ mammary tumor cells and required for tamoxifen-induced cellular senescence.
|
| Drug |
tamoxifen
|
| Disease |
ER+ mammary tumor
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|