| Name |
ZMPSTE24
|
| Type |
gene
|
| Species |
Mus musculus
|
| Tissue |
liver
|
| Experiment Method |
ChIP-on-chip microarrays,RNA sequencing,Western blot
|
| Up/Down |
Down
|
| Pro/Anti |
Anti
|
| Funtion Description |
Mutations in the nuclear envelope protein lamin A or in its processing protease ZMPSTE24 cause human accelerated aging syndromes, including Hutchinson-Gilford progeria syndrome. Similarly, Zmpste24-deficient mice accumulate unprocessed prelamin A and deve
|
| Regulation Gene |
NA
|
| Year |
2010
|
| Pubmed ID |
20961378
|
| Title |
Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|