| Name |
BMP7
|
| Type |
gene silence
|
| Species |
Homo sapiens
|
| Tissue |
Human breast cancer MCF-7 cell line
|
| Experiment Method |
Western blotting;RT-PCR;RNAi;cell fractionation and immunofluorescence staining;Luciferase gene reporter
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
The cytokine bone morphogenetic protein-7 (BMP7) induces the hTERT gene repression in a BMPRII receptor- and Smad3-dependent manner in human breast cancer cells. Chonic exposure of human breast cancer cells to BMP7 results in short telomeres, cell senesce
|
| Regulation Gene |
hTERT
|
| Year |
2017
|
| Pubmed ID |
27696331
|
| Title |
TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence
|
| Drug |
NA
|
| Disease |
breast cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|