Details
| Name | GADD45A |
| Type | gene silence |
| Species | Mus musculus |
| Tissue | skin |
| Experiment Method | RT-qPCR,other |
| Up/Down | Up |
| Pro/Anti | Anti |
| Funtion Description | Mice transfected with siGadd45a showed increased tumor incidence, size, and weight. Cells transfected with siGadd45a showed decrease in expression of Gadd45a and Bax; and increase in expression of Cyclin B1, MMP-2, and Bcl-2, expression of mutant p53, IL- |
| Regulation Gene | gene of mRNA of Gadd45a, Cyclin B1, MMP-2, Bcl-2, and Bax |
| Year | 2018 |
| Pubmed ID | 29663367 |
| Title | Gadd45a gene silencing by RNAi promotes cell proliferation and inhibits apoptosis and senescence in skin squamous cell carcinoma through the p53 signaling pathway. |
| Drug | NA |
| Disease | skin squamous carcinoma |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |