| Name |
MCL1
|
| Type |
gene silence
|
| Species |
Homo sapiens
|
| Tissue |
brain
|
| Experiment Method |
PCR,other
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
MCL1 silencing to influence glioma cell senescence and apoptosis through the mediation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway.The silencing of MCL1 resulted in a decrease in mRNA and protein expression of PI3
|
| Regulation Gene |
The gene of MCL1, PI3K, Akt, Bmi-1, and Bcl-2 and decreased that of Bax and PTEN
|
| Year |
2018
|
| Pubmed ID |
30296359
|
| Title |
MCL1 gene silencing promotes senescence and apoptosis of glioma cells via inhibition of the PI3K/Akt signaling pathway.
|
| Drug |
NA
|
| Disease |
glioma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|