A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name OCT4
Type histone modification
Species Homo sapiens
Tissue NA
Experiment Method RT-PCR
Up/Down Down
Pro/Anti Anti
Funtion Description Oct4 expression decreased phosphorylated histone H2AX (r-H2AX) focus formation and suppressed IRinduced premature senescence in these cells.
Regulation Gene 4-Oct
Year 2018
Pubmed ID 29749438
Title Oct4 suppresses IRinduced premature senescence in breast cancer cells through STAT3- and NFkB-mediated IL24 production.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA