Details
| Name | APTX |
| Type | histone modification |
| Species | Mus musculus |
| Tissue | NA |
| Experiment Method | RT-PCR, Western blot |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | Expression of SOD1(G93A) uncovers a survival defect ex vivo in cultured cells and in vivo in tissues lacking Aptx.The surviving neurons feature numerous and deep nuclear envelope invaginations, a hallmark of cellular stress.Furthermore, they possess an el |
| Regulation Gene | SOD1, IGF-1 |
| Year | 2015 |
| Pubmed ID | 25274775 |
| Title | Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing. |
| Drug | H2O2 |
| Disease | NA |
| Environment Factors | Aptx-/- |
| Circulating | 1 |
| Variant | NA |
| High-throughput | NA |