| Name |
ASF1
|
| Type |
histone modification
|
| Species |
Saccharomyces cerevisiae
|
| Tissue |
NA
|
| Experiment Method |
PCR, ChiP, Luciferase reporter assay, Western blot
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
We show that normal aging is accompanied by a profound loss of histone proteins from the genome. Indeed, yeast lacking the histone chaperone Asf1 or acetylation of histone H3 on lysine 56 are short lived, and this appears to be at least partly due to
|
| Regulation Gene |
ASF1
|
| Year |
2010
|
| Pubmed ID |
20832724
|
| Title |
Elevated histone expression promotes life span extension.
|
| Drug |
0
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|