Details
| Name | ASF1a |
| Type | histone modification |
| Species | Homo sapiens |
| Tissue | liver |
| Experiment Method | qPCR |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | ASF1a overexpression is widespread in human malignancies and is required for the infinite proliferation of cancer cells, whereas its inhibition induces DNA damage and subsequent up-regulation of p53-p21cip1 expression, thereby triggering cellular senescen |
| Regulation Gene | p53-p21cip1 |
| Year | 2019 |
| Pubmed ID | 30692519 |
| Title | ASF1a inhibition induces p53-dependent growth arrest and senescence of cancer cells. |
| Drug | NA |
| Disease | HCC |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |