| Name |
BACE1 promoter
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
brain
|
| Experiment Method |
Flow cytometric analysis, PCR, Western blotLuciferase reporter assay, ChIP
|
| Up/Down |
Down
|
| Pro/Anti |
Anti
|
| Funtion Description |
Our data show that galangin induces a decrease of acetylated H3 in the BACE1 promoter regions through the up-regulation of endogenous HDAC1-mediated deacetylation, which is independent of DNA methylation status.The above findings suggest a novel mechanism
|
| Regulation Gene |
BACE1
|
| Year |
2015
|
| Pubmed ID |
25779965
|
| Title |
Galangin-induced down-regulation of BACE1 by epigenetic mechanisms in SH-SY5Y cells.
|
| Drug |
galangin
|
| Disease |
Alzheimer's disease
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|