| Name |
BRCA1
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
Mammalian cells
|
| Experiment Method |
ChIP, qRT-pCR, in vitro Ubiquitination
|
| Up/Down |
Up
|
| Pro/Anti |
Anti
|
| Funtion Description |
We identified the histone variant macroH2A1 from the screen and showed that BRCA1/BARD1 ubiquitinates macroH2A1 at lysine 123 in vitro and in vivo. While mH2A is mainly characterized as a transcription repressor, Chen and colleagues recently reported that
|
| Regulation Gene |
BRCA1
|
| Year |
2019
|
| Pubmed ID |
28564596
|
| Title |
The Histone Variant MacroH2A1 Is a BRCA1 Ubiquitin Ligase Substrate.
|
| Drug |
0
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
1
|
| High-throughput |
NA
|