Details
| Name | C-MYC |
| Type | histone modification |
| Species | Mus musculus |
| Tissue | human medulloblastoma cell lines (D283-MED and DAOY) and a sPNET cell line |
| Experiment Method | qPCR |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | Valproic acid, at clinically safe concentrations (0.6 and 2 mmol/L), induced potent growth inhibition, cell cycle arrest, apoptosis, senescence, and differentiation and suppressed colony-forming efficiency and tumorigenicity in a time- and dose-dependent |
| Regulation Gene | CMYC |
| Year | 2005 |
| Pubmed ID | 16373706 |
| Title | Valproic acid induces growth arrest, apoptosis, and senescence in medulloblastomas by increasing histone hyperacetylation and regulating expression of p21Cip1, CDK5, and CMYC |
| Drug | NA |
| Disease | medulloblastomas |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |