| Name |
cyclin E promoter
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
Head and Neck
|
| Experiment Method |
PCR, ChiP, Western blot, Immunofluorescence
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Less acetylated histone H3 was observed on the cyclin E promoter in both SCC1 and SCC10B MUC4 KD cells as compared to the control cells (Figure 4d) confirming that cyclin E downregulation upon MUC4 KD is mediated by histone, In conclusion, our findings sh
|
| Regulation Gene |
cyclin E, p16, MUC4
|
| Year |
2014
|
| Pubmed ID |
24747969
|
| Title |
MUC4 regulates cellular senescence in head and neck squamous cell carcinoma through p16/Rb pathway.
|
| Drug |
Trichostatin A (TSA)
|
| Disease |
head and neck squamous carcinoma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|